Hydrochloric Acid → HCID 68292626, compound

HRID 2276914Notes

Reaction equation

HRID 2276914 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](C)([C:14](O)=O)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.[ClH:18]>CO>[ClH:18].[CH3:1][O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH3:14])[CH2:10][CH2:9]1)=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 232828481-[(Tert-butoxy)carbonyl]-4-methylpiperidine-4-carboxylic acid

Product 1

HCID 68292626HCID 68292626, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 4-methyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.00 g, 4.10 mmol) in MeOH (2 mL) is added HCl (5 ml, 4 M in dioxane). After 18 h, the mixture is evaporated to dryness, the residue is dissolved in MeOH (3 mL), and the stirred solution is treated with Et2O (45 ml). The resulting solid is filtered and dried to give the title compound.

Workup

  1. customthe mixture is evaporated to dryness
  2. dissolutionthe residue is dissolved in MeOH (3 mL)
  3. additionthe stirred solution is treated with Et2O (45 ml)
  4. filtrationThe resulting solid is filtered
  5. customdried

Sources & evidence

ORD record
ord-22392b13b11242968313ba785736af62
Source dataset
uspto-grants-2015_09
Patent number
US09133146B2

Reaction notes

Loading…