Potassium trifluoro[(pyrrolidin-1-yl)methyl]borate → 1-[4-(7-Fluoro-2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-pyrrolidine

HRID 2276917Notes

Reaction equation

HRID 2276917 reaction equation
[B-](F)(F)(F)CN1CCCC1.[K+].[F:12][C:13]1[CH:14]=[CH:15][C:16]2[O:21][CH2:20][CH:19]([C:22]3[CH:34]=[CH:33][C:25]([CH2:26][N:27]4[CH2:32][CH2:31]O[CH2:29][CH2:28]4)=[CH:24][CH:23]=3)[O:18][C:17]=2[CH:35]=1>>[F:12][C:13]1[CH:14]=[CH:15][C:16]2[O:21][CH2:20][CH:19]([C:22]3[CH:23]=[CH:24][C:25]([CH2:26][N:27]4[CH2:32][CH2:31][CH2:29][CH2:28]4)=[CH:33][CH:34]=3)[O:18][C:17]=2[CH:35]=1

Participants

3

Reactant 2

HCID 45588176Potassium trifluoro[(pyrrolidin-1-yl)methyl]borateHCID 68292423HCID 68292423, compound

Product 1

HCID 682926911-[4-(7-Fluoro-2,3-dihydro-benzo[1,4]dioxin-2-yl)-benzyl]-pyrrolidine

Procedure

The title compound is prepared from G-4 and Potassium 1-trifluoroboratomethylpyrrolidine according to the procedure described for the synthesis of compound 202. 203: LC/MS Method 10; Rt=1.07 min.; [M+H]+=354.4.

Sources & evidence

ORD record
ord-4ea7a01a7dc34a4e91e7b4bf66c76cbb
Source dataset
uspto-grants-2015_09
Patent number
US09133146B2

Reaction notes

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