反应详情

(S)-2-Benzyloxycarbonylamino-3-tert-butoxy-propionic acid cyclopentyl ester (3.82 g, 0.011 mol) was dissolved in EtOH (50 ml). 20% wt. Palladium hydroxide (wet) was added cautiously to the solution. The system was evacuated and put under a hydrogen atmosphere for 4 hours. The system was evacuated and the palladium residues filtered off through Celite. The Celite was thoroughly washed with EtOH (3×5 ml). The solvent of the filtrate was removed in vacuo to give the product as a colourless oil (2.41 g, 100% yield). 1H NMR (300 MHz, CDCl3), δ: 1.15 (9H, s, CH3×3), 1.50-1.90 (10H, m, CH2×4, NH2), 3.50-3.70 (3H, m, CH2, CH), 5.22 (1H, s, CH).

1. customThe system was evacuated
2. customThe system was evacuated
3. filtrationthe palladium residues filtered off through Celite
4. washThe Celite was thoroughly washed with EtOH (3×5 ml)
5. customThe solvent of the filtrate was removed in vacuo