Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 57443968 | HCID 57443968 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 13540122 | HCID 13540122 | — |
Reaction Steps
6-Hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester (2.4 g, 9.6 mmol, 1 eq) was dissolved in THF (10 mL, 4 vol) and water added (10 mL) along with LiOH (0.69 g, 28.8 mmol). The reaction mixture was stirred at 50° C. for 3 h and then concentrated to dryness and taken onto the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09133104B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-6456dfba4d4d44798ea9159b2ddb5f67 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
