Water → HCID 13540122, compound

HRID 2276964Notes

Reaction equation

HRID 2276964 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]2[CH:11]=[C:12]([CH2:15][OH:16])[CH:13]=[CH:14][C:8]=2[CH:7]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[OH:16][CH2:15][C:12]1[CH:13]=[CH:14][C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:10][C:9]=2[CH:11]=1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 57443968HCID 57443968, compound

Product 1

HCID 13540122HCID 13540122, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

6-Hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester (2.4 g, 9.6 mmol, 1 eq) was dissolved in THF (10 mL, 4 vol) and water added (10 mL) along with LiOH (0.69 g, 28.8 mmol). The reaction mixture was stirred at 50° C. for 3 h and then concentrated to dryness and taken onto the next step without purification.

Workup

  1. concentrationconcentrated to dryness
  2. customtaken onto the next step without purification

Sources & evidence

ORD record
ord-6456dfba4d4d44798ea9159b2ddb5f67
Source dataset
uspto-grants-2015_09
Patent number
US09133104B2

Reaction notes

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