Hydrogen Bromide → HCID 53770707, compound

HRID 2276978Notes

Reaction equation

HRID 2276978 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9]O)[CH:5]=[CH:6][CH:7]=1.[BrH:11]>>[Br:11][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([NH2:1])[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 149389872-(3-Aminophenyl)ethan-1-ol

Product 1

HCID 53770707HCID 53770707, compoundYield 61%

Procedure

A solution of 2-(3-Amino-phenyl)-ethanol (2.0 g) in 48% aq HBr (20 ml) was heated at 90° C. for 18 h. The mixture was cooled to room temperature, and the precipitate formed was collected by filtration. The solid was dried in vacuo yielding Building block M, 1.8 g (61% yield). LCMS purity 90%, m/z 200/202 [M+H]+.

Workup

  1. customthe precipitate formed
  2. filtrationwas collected by filtration
  3. customThe solid was dried in vacuo
  4. customyielding Building block M, 1.8 g (61% yield)

Sources & evidence

ORD record
ord-949c2d5d039142a985d4c686b07a0a3b
Source dataset
uspto-grants-2015_09
Patent number
US09133104B2

Reaction notes

Loading…