反应详情

6-(Hydroxymethyl)piperidin-2-one (1.0 g, 7.8 mmol) and Et3N (1.1 ml, 7.8 mmol) in DCM (5 ml) was added into mesyl chloride (0.88 g, 7.8 mmol) in DCM (20 ml) at 0° C. The reaction mixture was stirred at room temperature for 15 mins. The reaction mixture was washed with 1 N HCl (20 ml) and brine (40 ml), dried over anhydrous Na2SO4 and concentrated under reduced pressure to give (6-oxopiperidin-2-yl)methyl methanesulfonate which was used in the next step without additional purification. Yield (quant.).

1. washThe reaction mixture was washed with 1 N HCl (20 ml) and brine (40 ml)
2. dry with materialdried over anhydrous Na2SO4
3. concentrationconcentrated under reduced pressure