(R)-tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamate → HCID 90405419, compound

HRID 2277072Notes

Reaction equation

HRID 2277072 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[C:11]([O:13]CC)=O.O[C@@H](C1C=CC=C(O)C=1)[CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C>C(#N)C>[O:13]=[C:11]([C:10]1[CH:16]=[CH:17][CH:18]=[C:8]([O:7][CH2:6][C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[CH:9]=1)[CH2:21][C:22]#[N:23]

Participants

4

Reactant 2

HCID 90405310(R)-tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamate2×HCID 90405497HCID 90405497, compound

Product 1

HCID 90405419HCID 90405419, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Condensation between ethyl 3-(thiophen-2-ylmethoxy)benzoate and acetonitrile following the method used in the preparation of phenol (Intermediate I) gave after flash column chromatography 3-oxo-3-(3-(thiophen-2-ylmethoxy)phenyl)propanenitrile as a colorless oil.

Sources & evidence

ORD record
ord-d1be2a4367ea4d1b9b9083a525eb1d8c
Source dataset
uspto-grants-2015_09
Patent number
US09133154B2

Reaction notes

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