5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine → N-((2S)-1-((2-(6-(cyclopropylmethoxy)-5-fluoropyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

HRID 2277157Notes

Reaction equation

HRID 2277157 reaction equation
[O:1]1[C:5]2[CH:6]=[C:7]([O:10][CH2:11][C@@H:12]([NH:14][C:15](=[O:17])[CH3:16])[CH3:13])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.Br[C:19]1[CH:20]=[C:21]([F:30])[C:22]([O:25][CH2:26][CH:27]2[CH2:29][CH2:28]2)=[N:23][CH:24]=1>>[CH:27]1([CH2:26][O:25][C:22]2[N:23]=[CH:24][C:19]([C:2]3[O:1][C:5]4[CH:6]=[C:7]([O:10][CH2:11][C@@H:12]([NH:14][C:15](=[O:17])[CH3:16])[CH3:13])[CH:8]=[CH:9][C:4]=4[N:3]=3)=[CH:20][C:21]=2[F:30])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 867151175-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridineHCID 86731211N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide

Product 1

HCID 86731210N-((2S)-1-((2-(6-(cyclopropylmethoxy)-5-fluoropyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide and 5-bromo-2-(cyclopropylmethoxy)-3-fluoropyridine, and in the same manner as in Step B of Example 22, the title compound was obtained.

Sources & evidence

ORD record
ord-175754d848c4464086c0b6a6195c8fb5
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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