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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2277157Generated: October 31, 2026

5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine → N-((2S)-1-((2-(6-(cyclopropylmethoxy)-5-fluoropyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

https://huagongshe.com/reaction/2277157

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridineHCID 86715117—
ReactantN-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamideHCID 86731211—
ProductN-((2S)-1-((2-(6-(cyclopropylmethoxy)-5-fluoropyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamideHCID 86731210—

Reaction Steps

Using N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide and 5-bromo-2-(cyclopropylmethoxy)-3-fluoropyridine, and in the same manner as in Step B of Example 22, the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133129B2
Source datasetuspto-grants-2015_09
ORD IDord-175754d848c4464086c0b6a6195c8fb5
Source noteuspto-grants-2015_09