N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide → N-((2S)-1-((2-(5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

HRID 2277163Notes

Reaction equation

HRID 2277163 reaction equation
[O:1]1[C:5]2[CH:6]=[C:7]([O:10][CH2:11][C@@H:12]([NH:14][C:15](=[O:17])[CH3:16])[CH3:13])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.Br[C:19]1[CH:20]=[C:21]([Cl:30])[C:22]([O:25][CH2:26][CH:27]2[CH2:29][CH2:28]2)=[N:23][CH:24]=1>>[Cl:30][C:21]1[CH:20]=[C:19]([C:2]2[O:1][C:5]3[CH:6]=[C:7]([O:10][CH2:11][C@@H:12]([NH:14][C:15](=[O:17])[CH3:16])[CH3:13])[CH:8]=[CH:9][C:4]=3[N:3]=2)[CH:24]=[N:23][C:22]=1[O:25][CH2:26][CH:27]1[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 86731211N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamideHCID 867312155-Bromo-3-chloro-2-(cyclopropylmethoxy)pyridine

Product 1

HCID 86731216N-((2S)-1-((2-(5-chloro-6-(cyclopropylmethoxy)pyridin-3-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide and 5-bromo-3-chloro-2-(cyclopropylmethoxy)pyridine, and in the same manner as in Step B of Example 22, the title compound was obtained.

Sources & evidence

ORD record
ord-21cbf7d0838b44458825df8cbd28711f
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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