HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86731249, compound → HCID 136341405, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86731249 | HCID 86731249 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 136341405 | HCID 136341405 | 96.3% |
Reaction Steps
A mixture of N-((2S)-1-((2-(4-(benzyloxy)-3-fluorophenyl)-7-fluoro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1.05 g), 10% palladium-carbon (containing water (50%), 1.00 g) and THF (10 mL) was stirred at room temperature for 30 min under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (810 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-e6537c2a4e4e492b970bee55158c4736 |
| Source note | uspto-grants-2015_09 |