HCID 86731249, compound → HCID 136341405, compound

HRID 2277191Notes

Reaction equation

HRID 2277191 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[C:23]([F:24])=[C:22]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[CH:21]=[CH:20][C:18]=3[N:19]=2)=[CH:11][C:10]=1[F:33])C1C=CC=CC=1>[C].[Pd].C1COCC1>[F:24][C:23]1[C:17]2[O:16][C:15]([C:12]3[CH:13]=[CH:14][C:9]([OH:8])=[C:10]([F:33])[CH:11]=3)=[N:19][C:18]=2[CH:20]=[CH:21][C:22]=1[O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28]

Participants

4

Reactant 1

HCID 86731249HCID 86731249, compound

Product 1

HCID 136341405HCID 136341405, compoundYield 96.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-((2S)-1-((2-(4-(benzyloxy)-3-fluorophenyl)-7-fluoro-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1.05 g), 10% palladium-carbon (containing water (50%), 1.00 g) and THF (10 mL) was stirred at room temperature for 30 min under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (810 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e6537c2a4e4e492b970bee55158c4736
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

Loading…