反应详情

After repetition of the reaction so described, a mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-3,4-dihydroquinazolin-4-one (20.3 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times to give 7-benzyloxy-4-chloro-6-methoxyquinazoline.

1. customAfter repetition of the reaction
2. temperaturewas heated
3. temperatureto reflux for 4 hours
4. customThe thionyl chloride was evaporated under vacuum
5. customthe residue was azeotroped with toluene three times