Hydrochloric Acid → HCID 86731315, compound

Participants

Reaction Steps

To a solution of methyl 5-(cyclopropylmethoxy)-4-fluoropyridine-2-carboxylate (1.07 g) in a mixed solvent of THF (10 mL) and methanol (1.1 mL) was added 2 M lithium hydroxide aqueous solution (4.75 mL), and the mixture was stirred at room temperature for 20 min. The reaction mixture was allowed to cool to room temperature, and neutralized with 1 M hydrochloric acid, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained solid was washed with diethyl ether/hexane to give the title compound (0.950 g).

Provenance & Evidence