Hydrochloric Acid → HCID 86731315, compound

To a solution of methyl 5-(cyclopropylmethoxy)-4-fluoropyridine-2-carboxylate (1.07 g) in a mixed solvent of THF (10 mL) and methanol (1.1 mL) was added 2 M lithium hydroxide aqueous solution (4.75 mL), and the mixture was stirred at room temperature for 20 min. The reaction mixture was allowed to cool to room temperature, and neutralized with 1 M hydrochloric acid, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained solid was washed with diethyl ether/hexane to give the title compound (0.950 g).

1. temperatureto cool to room temperature
2. extractionthe mixture was extracted with ethyl acetate
3. washThe obtained organic layer was washed with saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe solvent was evaporated under reduced pressure
6. washThe obtained solid was washed with diethyl ether/hexane

ORD record

ord-e0bd5de781fc464fae566325c11888ac

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09133129B2