反应详情

To a solution of 5-(benzyloxy)pyridin-2-amine (10.2 g) in acetic acid (50 mL) was added bromine (2.61 mL) at 0° C., and the mixture was stirred for 2 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (8.50 g).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate
3. customthe solvent was evaporated
4. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate)