5-Bromo-2-(cyclopropylmethoxy)pyrimidine → N-((2S)-1-((2-(2-(cyclopropylmethoxy)pyrimidin-5-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

HRID 2277254Notes

Reaction equation

HRID 2277254 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]([O:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1.[O:13]1[C:17]2[CH:18]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])[CH:20]=[CH:21][C:16]=2[N:15]=[CH:14]1>>[CH:10]1([CH2:9][O:8][C:5]2[N:4]=[CH:3][C:2]([C:14]3[O:13][C:17]4[CH:18]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])[CH:20]=[CH:21][C:16]=4[N:15]=3)=[CH:7][N:6]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 638684135-Bromo-2-(cyclopropylmethoxy)pyrimidineHCID 86731211N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide

Product 1

HCID 86731326N-((2S)-1-((2-(2-(cyclopropylmethoxy)pyrimidin-5-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using 5-bromo-2-(cyclopropylmethoxy)pyrimidine and N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide, and in the same manner as in Step B of Example 22, the title compound was obtained.

Sources & evidence

ORD record
ord-c2de321a6e5f4dfca896131783bbf4e8
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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