(1-Fluorocyclopropyl)methanol → N-((2S)-1-((2-(3,5-difluoro-4-((1-fluorocyclopropyl)methoxy)phenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

HRID 2277256Notes

Reaction equation

HRID 2277256 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[CH:22]=[CH:21][C:19]=3[N:20]=2)=[CH:11][C:10]=1[F:33])[C:2]1[CH:7]=[CH:6]C=CC=1.[F:34]C1(CO)CC1>>[F:33][C:10]1[CH:11]=[C:12]([C:16]2[O:17][C:18]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[CH:22]=[CH:21][C:19]=3[N:20]=2)[CH:13]=[C:14]([F:15])[C:9]=1[O:8][CH2:1][C:2]1([F:34])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 67149022(1-Fluorocyclopropyl)methanolHCID 86731330N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Product 1

HCID 86731329N-((2S)-1-((2-(3,5-difluoro-4-((1-fluorocyclopropyl)methoxy)phenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide and (1-fluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.

Sources & evidence

ORD record
ord-8dbf14d6980a44fdb309168582917ddf
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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