Iodoethane → N-((2S)-1-((2-(4-ethoxy-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

HRID 2277269Notes

Reaction equation

HRID 2277269 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[CH:22]=[CH:21][C:19]=3[N:20]=2)=[CH:11][C:10]=1[F:33])[C:2]1C=CC=CC=1.ICC>>[CH2:1]([O:8][C:9]1[C:10]([F:33])=[CH:11][C:12]([C:16]2[O:17][C:18]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[CH:22]=[CH:21][C:19]=3[N:20]=2)=[CH:13][C:14]=1[F:15])[CH3:2]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 86731330N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Product 1

HCID 86731346N-((2S)-1-((2-(4-ethoxy-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide and iodoethane, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-2be6dd7050c1401d816c3810d685cdad
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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