4-Nitrophenyl chloroformate → HCID 86731358, compound

HRID 2277277Notes

Reaction equation

[F:1][C:2]1([F:37])[CH2:4][C@@H:3]1[CH2:5][O:6][C:7]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=O)[O:29]C(C)(C)C)[CH3:26])[N:20]=[CH:19][C:18]=3[N:35]=2)=[CH:9][C:8]=1[F:36].C(Cl)(=O)OC1C=CC([N+:46]([O-])=O)=CC=1>>[F:37][C:2]1([F:1])[CH2:4][C@@H:3]1[CH2:5][O:6][C:7]1[C:12]([O:13][CH3:14])=[CH:11][C:10]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28]([NH2:46])=[O:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:35]=2)=[CH:9][C:8]=1[F:36]

Participants

Reactant 2

HCID 821294-Nitrophenyl chloroformate

HCID 86731359HCID 86731359, compound

Product 1

HCID 86731358HCID 86731358, compound

Procedure

Using tert-butyl ((2S)-1-((2-(4-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoro-5-methoxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)carbamate and 4-nitrophenyl carbonochloridate, and in the same manner as in Example 59, the title compound was obtained.

Sources & evidence

ORD record: ord-44ce862d0e3c48bca23d5252614e3c27
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133129B2

Reaction notes

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