HCID 57755841, compound → HCID 57755851, compound

HRID 227728Notes

Reaction equation

HRID 227728 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([N+:18]([O-])=O)[CH:16]=3)[NH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([NH2:18])[CH:16]=3)[NH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 57755841HCID 57755841, compound

Product 1

HCID 57755851HCID 57755851, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (3-Fluoro-phenyl)-(5-nitro-1H-indazol-3-yl)-amine (0.36 g, 1.3 mmol) in methanol (10 ml) was added 10% Pd/C (72 mg). The mixture was allowed to stir at room temperature under H2 atmosphere. After TLC showed the starting material to be consumed, the reaction was passed through a plug of celite. The filtrate was concentrated to give the title compound as an off-white solid. MS (ESI) m/z=243 [M+H]+.

Workup

  1. customto be consumed
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-7076824491ec4c438911c90e1744d6ca
Source dataset
uspto-grants-2009_07
Patent number
US07560467B2

Reaction notes

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