Bromomethylcyclopropane → HCID 86731363, compound

HRID 2277281Notes

Reaction equation

[F:1][CH:2]([F:28])[O:3][C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[N:16]=[CH:15][C:14]=3[N:27]=2)[CH:7]=[CH:8][C:9]=1[OH:10].Br[CH2:30][CH:31]1[CH2:33][CH2:32]1>>[CH:31]1([CH2:30][O:10][C:9]2[CH:8]=[CH:7][C:6]([C:11]3[O:12][C:13]4[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[N:16]=[CH:15][C:14]=4[N:27]=3)=[CH:5][C:4]=2[O:3][CH:2]([F:1])[F:28])[CH2:33][CH2:32]1

Participants

Reactant 2

HCID 81503Bromomethylcyclopropane

HCID 136341409HCID 136341409, compound

Product 1

HCID 86731363HCID 86731363, compound

Procedure

Using N-((2S)-1-((2-(3-(difluoromethoxy)-4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (bromomethyl)cyclopropane, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record: ord-e8b55b5be1b04e72af9102dce39ac23e
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133129B2

Reaction notes

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