4-(Cyclopropylmethoxy)-2-methylbenzoic acid → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-methylphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277283Notes

Reaction equation

HRID 2277283 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[C:8]([CH3:15])[CH:7]=2)[CH2:3][CH2:2]1.Cl[C:17]1[C:22]([N+:23]([O-])=O)=[CH:21][N:20]=[C:19]([O:26][CH2:27][C@@H:28]([NH:30][C:31](=[O:33])[CH3:32])[CH3:29])[CH:18]=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10]3[O:12][C:17]4[CH:18]=[C:19]([O:26][CH2:27][C@@H:28]([NH:30][C:31](=[O:33])[CH3:32])[CH3:29])[N:20]=[CH:21][C:22]=4[N:23]=3)=[C:8]([CH3:15])[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 580473504-(Cyclopropylmethoxy)-2-methylbenzoic acidHCID 86731225N-((2S)-1-((4-chloro-5-nitropyridin-2-yl)oxy)propan-2-yl)acetamide

Product 1

HCID 86731366N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-methylphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using 4-(cyclopropylmethoxy)-2-methylbenzoic acid and N-((2S)-1-((4-chloro-5-nitropyridin-2-yl)oxy)propan-2-yl)acetamide, and in the same manner as in Step B and Step C of Example 31, the title compound was obtained.

Sources & evidence

ORD record
ord-13b0a1232aff4e38bd47b6164678071b
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

Loading…