Hydrochloric Acid → HCID 60791485, compound

Participants

Reaction Steps

To a solution of cyclopropylmethyl 6-(cyclopropylmethoxy)pyridazine-3-carboxylate (0.48 g) in a mixed solvent of THF (5 mL) and methanol (5 mL) was added 1 M aqueous lithium hydroxide solution (5 mL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was neutralized with 1 M hydrochloric acid, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (0.40 g).

Provenance & Evidence