Hydrochloric Acid → HCID 60791485, compound

HRID 2277285Notes

Reaction equation

HRID 2277285 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[N:10][C:9]([C:12]([O:14]CC3CC3)=[O:13])=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.C1COCC1.[OH-].[Li+].Cl>CO>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[N:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=2)[CH2:2][CH2:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 86731367HCID 86731367, compound

Product 1

HCID 60791485HCID 60791485, compoundYield 106.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of cyclopropylmethyl 6-(cyclopropylmethoxy)pyridazine-3-carboxylate (0.48 g) in a mixed solvent of THF (5 mL) and methanol (5 mL) was added 1 M aqueous lithium hydroxide solution (5 mL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was neutralized with 1 M hydrochloric acid, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (0.40 g).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe obtained organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cb02168c44b84cdd8eaf93b5a676ddaf
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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