反应详情

Iodine (1.6 g, 6.4 mmol) and KOH (0.67 g, 12 mmol) were successfully added into a solution of 5-nitro-1H-indazole (520 mg, 3.2 mmol) in DMF. The reaction mixture was stirred at room temperature for overnight and then 10% Na2S2O5 was poured into the mixture. The titled compound (0.84 g, 91%) was filtered off as a yellow solid. MS (ESI) m/z=290 [M+H]+. 1H NMR (400 MHz, d6-DMSO) δ 14.15(s, 1H), 8.36(d, J=2 Hz, 1H), 8.26 (dd, J=2 and 9 Hz, 1H), 7.78 (d, J=9 Hz, 1H)

1. filtrationThe titled compound (0.84 g, 91%) was filtered off as a yellow solid