4-((2,2-Difluorocyclopropyl)methoxy)benzoic acid → HCID 178461782, compound

HRID 2277293Notes

Reaction equation

HRID 2277293 reaction equation
C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[F:30][C:31]1([F:45])[CH2:33][CH:32]1[CH2:34][O:35][C:36]1[CH:44]=[CH:43][C:39]([C:40](O)=[O:41])=[CH:38][CH:37]=1>>[F:30][C:31]1([F:45])[CH2:33][CH:32]1[CH2:34][O:35][C:36]1[CH:44]=[CH:43][C:39]([C:40]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:41])=[CH:38][CH:37]=1

Participants

3

Reactant 2

HCID 690200884-((2,2-Difluorocyclopropyl)methoxy)benzoic acidHCID 86731375tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate

Product 1

HCID 178461782HCID 178461782, compound

Procedure

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 4-((2,2-difluorocyclopropyl)methoxy)benzoic acid, and in the same manner as in Step A of Example 4 and Step D of Example 83, the title compound was obtained.

Sources & evidence

ORD record
ord-523a86e6d94042bb8dc638331938765d
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

Loading…