2-[(1S)-2-Hydroxy-1-methylethyl]-1H-isoindole-1,3(2H)-dione → HCID 86731385, compound

HRID 2277303Notes

Reaction equation

HRID 2277303 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([OH:8])=[N:6][CH:7]=1.O[CH2:11][C@@H:12]([N:14]1[C:22](=[O:23])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]1=[O:24])[CH3:13]>>[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([O:8][CH2:13][C@@H:12]([N:14]2[C:22](=[O:23])[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]2=[O:24])[CH3:11])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 124997532-[(1S)-2-Hydroxy-1-methylethyl]-1H-isoindole-1,3(2H)-dioneHCID 1785175945-Bromo-3-fluoro-1,2-dihydropyridin-2-one

Product 1

HCID 86731385HCID 86731385, compound

Procedure

Using 5-bromo-3-fluoropyridin-2-ol and 2-((2S)-1-hydroxypropan-2-yl)-1H-isoindole-1,3(2H)-dione, and in the same manner as in Step C of Example 1, the title compound was obtained.

Sources & evidence

ORD record
ord-29c4e9f52e2c421b97388d574e09618f
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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