tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate → HCID 178461786, compound

HRID 2277309Notes

Reaction equation

HRID 2277309 reaction equation
C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[F:30][C:31]1([F:46])[CH2:33][C@@H:32]1[CH2:34][O:35][C:36]1[CH:37]=[C:38]([F:45])[C:39]([C:42](O)=[O:43])=[N:40][CH:41]=1>>[F:46][C:31]1([F:30])[CH2:33][C@@H:32]1[CH2:34][O:35][C:36]1[CH:37]=[C:38]([F:45])[C:39]([C:42]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:43])=[N:40][CH:41]=1

Participants

3

Reactant 2

HCID 86731375tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamateHCID 867313845-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylic Acid

Product 1

HCID 178461786HCID 178461786, compound

Procedure

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 5-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylic acid, and in the same manner as in Step A of Example 4 and Step D of Example 83, the title compound was obtained.

Sources & evidence

ORD record
ord-71ca2098d3bd44e78e920380efbedd95
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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