(2,2-Difluoro-1-methylcyclopropyl)methanol → N-((2S)-1-((2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)-3-fluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277331Notes

Reaction equation

HRID 2277331 reaction equation
[F:1][C:2]1([F:8])[CH2:4][C:3]1([CH2:6][OH:7])[CH3:5].[F:9][C:10]1[CH:11]=[C:12]([C:17]2[O:18][C:19]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[N:22]=[CH:21][C:20]=3[N:33]=2)[CH:13]=[CH:14][C:15]=1O>>[F:1][C:2]1([F:8])[CH2:4][C:3]1([CH2:6][O:7][C:15]1[CH:14]=[CH:13][C:12]([C:17]2[O:18][C:19]3[CH:24]=[C:23]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:32])[CH3:31])[CH3:28])[N:22]=[CH:21][C:20]=3[N:33]=2)=[CH:11][C:10]=1[F:9])[CH3:5]

Participants

3

Reactant 2

HCID 14695233(2,2-Difluoro-1-methylcyclopropyl)methanolHCID 136341410HCID 136341410, compound

Product 1

HCID 86731422N-((2S)-1-((2-(4-((2,2-difluoro-1-methylcyclopropyl)methoxy)-3-fluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using (2,2-difluoro-1-methylcyclopropyl)methanol and N-((2S)-1-((2-(3-fluoro-4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide, and in the same manner as in Step B of Example 4, the title compound was obtained.

Sources & evidence

ORD record
ord-d213687fbb534a8ba2fd31ff1b1e2098
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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