3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid → HCID 178461780, compound

HRID 2277333Notes

Reaction equation

HRID 2277333 reaction equation
[Cl:1][C:2]1[C:3]([C:15]([OH:17])=O)=[N:4][CH:5]=[C:6]([O:8][CH2:9][C@H:10]2[CH2:12][C:11]2([F:14])[F:13])[CH:7]=1.[NH2:18][C:19]1[C:20]([OH:37])=[CH:21][C:22]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH3:28])=[N:23][CH:24]=1>>[Cl:1][C:2]1[C:3]([C:15]([NH:18][C:19]2[C:20]([OH:37])=[CH:21][C:22]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:34])([CH3:33])[CH3:35])[CH3:28])=[N:23][CH:24]=2)=[O:17])=[N:4][CH:5]=[C:6]([O:8][CH2:9][C@H:10]2[CH2:12][C:11]2([F:13])[F:14])[CH:7]=1

Participants

3

Reactant 2

HCID 867313973-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acidHCID 178461779HCID 178461779, compound

Product 1

HCID 178461780HCID 178461780, compound

Procedure

Using 3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid and tert-butyl ((2S)-1-((5-amino-4-hydroxypyridin-2-yl)oxy)propan-2-yl)carbamate, and in the same manner as in Step E of Example 139, the title compound was obtained.

Sources & evidence

ORD record
ord-fcdee00c12ab4e29af94c24791ca075b
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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