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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2277333Generated: October 29, 2026

3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid → HCID 178461780, compound

https://huagongshe.com/reaction/2277333

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acidHCID 86731397—
ReactantHCID 178461779HCID 178461779—
ProductHCID 178461780HCID 178461780—

Reaction Steps

Using 3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid and tert-butyl ((2S)-1-((5-amino-4-hydroxypyridin-2-yl)oxy)propan-2-yl)carbamate, and in the same manner as in Step E of Example 139, the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133129B2
Source datasetuspto-grants-2015_09
ORD IDord-fcdee00c12ab4e29af94c24791ca075b
Source noteuspto-grants-2015_09