4-(benzyloxy)-3,5-difluorobenzoic Acid → HCID 178461784, compound

HRID 2277337Notes

Reaction equation

HRID 2277337 reaction equation
C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[CH2:30]([O:37][C:38]1[C:46]([F:47])=[CH:45][C:41]([C:42](O)=[O:43])=[CH:40][C:39]=1[F:48])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:30]([O:37][C:38]1[C:39]([F:48])=[CH:40][C:41]([C:42]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:43])=[CH:45][C:46]=1[F:47])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 631837474-(benzyloxy)-3,5-difluorobenzoic AcidHCID 86731375tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate

Product 1

HCID 178461784HCID 178461784, compound

Procedure

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 4-(benzyloxy)-3,5-difluorobenzoic acid, and in the same manner as in Step A of Example 4, Step D of Example 83 and Step B of Example 123, the title compound was obtained.

Sources & evidence

ORD record
ord-409b50a9ff734434906b4b5cbfc7ec9c
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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