Tetrahydrofuran → tert-butyl ((2S)-1-((2-(4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)carbamate

Participants

Reaction Steps

A mixture of tert-butyl ((2S)-1-((2-(4-(benzyloxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)carbamate (2.5 g), 10% palladium/carbon (containing water (50%), 0.5 g), THF (200 mL) and DMF (50 mL) was stirred for 15 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure. The obtained solid was collected by filtration, washed with hexane/ethyl acetate (4/1), dried to give the title compound (1.45 g).

Provenance & Evidence