反应详情

A mixture of tert-butyl ((2S)-1-((2-(4-(benzyloxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)carbamate (2.5 g), 10% palladium/carbon (containing water (50%), 0.5 g), THF (200 mL) and DMF (50 mL) was stirred for 15 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure. The obtained solid was collected by filtration, washed with hexane/ethyl acetate (4/1), dried to give the title compound (1.45 g).

1. customThe catalyst was removed by filtration
2. concentrationthe obtained filtrate was concentrated under reduced pressure
3. filtrationThe obtained solid was collected by filtration
4. washwashed with hexane/ethyl acetate (4/1)
5. customdried