Cesium carbonate → HCID 60172482, compound

HRID 2277376Notes

Reaction equation

HRID 2277376 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:20][C:21]([C:23]2[C:24](=[O:36])[N:25]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[N:26]([CH3:29])[C:27]=2[CH3:28])=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=2)[N:12]=[CH:11][CH:10]=1.[CH3:37][C@H:38]1[CH2:40][O:39]1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[F:1][C:2]1[CH:3]=[C:4]([NH:20][C:21]([C:23]2[C:24](=[O:36])[N:25]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:26]([CH3:29])[C:27]=2[CH3:28])=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH2:37][C@@H:38]([OH:39])[CH3:40])=[CH:16][CH:17]=2)[N:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 146262(2S)-2-MethyloxiraneHCID 136347997N-(3-fluoro-4-((7-hydroxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Product 1

HCID 60172482HCID 60172482, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to the procedure described in Example 2 by using N-(3-fluoro-4-((7-hydroxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (1.00 g, 2.07 mmol), (S)-2-methyloxirane (1.44 mL, 20.70 mmol) and Cs2CO3 (1.35 g, 4.14 mmol) in 10 mL DMF. The title compound was obtained as a white solid (663 mg, 55%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-571634aeaefe408e8ca426895c41498e
Source dataset
uspto-grants-2015_09
Patent number
US09133162B2

Reaction notes

Loading…