反应详情

A suspension of 7-(benzyloxy)-6-methoxy-4-(4-nitrophenoxy)quinoline (43.00 g, 120 mmol), 10% Pd/C (4.30 g) and HCOOK (89.93 g, 600 mmol) in MeOH/H2O (345 mL/200 mL) was refluxed overnight. The mixture was cooled to room temperature, diluted with EtOAc (300 mL) and filtered through a celite pad. The filtrate was concentrated in vacuo and the residue was washed with water, dried in vacuo at 60° C. overnight to give the title compound as a yellow solid (28.8 g, 95.5%).

1. temperaturewas refluxed overnight
2. filtrationfiltered through a celite pad
3. concentrationThe filtrate was concentrated in vacuo
4. washthe residue was washed with water
5. customdried in vacuo at 60° C. overnight