HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyridyl)piperazine → N-{1-Methyl-2-[(4-pyridin-2-yl-piperazin-1-yl)carbonyl]-1H-imidazol-4-yl}-N'-[4-(trifluoromethoxy)phenyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-Methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic Acid | HCID 59421802 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{1-Methyl-2-[(4-pyridin-2-yl-piperazin-1-yl)carbonyl]-1H-imidazol-4-yl}-N'-[4-(trifluoromethoxy)phenyl]urea | HCID 11858022 | — |
Reaction Steps
1.50 g (4.36 mmol) of the compound of Example 4A is dissolved in 30 ml of DMF and mixed with 1.82 g (5.66 mmol) of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU) and 266 mg (2.18 mmol) of 4-dimethylaminopyridine. After adding 925 mg (5.66 mmol) of 1-(pyridin-2-yl)-piperazine, it is allowed to stir for 4 hours at room temperature. The reaction mixture is purified by RP-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133165B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-8aa9c0bcccca4aea9e08358dbb41e03c |
| Source note | uspto-grants-2015_09 |