反应详情

1.50 g (4.36 mmol) of the compound of Example 4A is dissolved in 30 ml of DMF and mixed with 1.82 g (5.66 mmol) of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (TBTU) and 266 mg (2.18 mmol) of 4-dimethylaminopyridine. After adding 925 mg (5.66 mmol) of 1-(pyridin-2-yl)-piperazine, it is allowed to stir for 4 hours at room temperature. The reaction mixture is purified by RP-HPLC.

1. customThe reaction mixture is purified by RP-HPLC