Hydrochloric Acid → HCID 70874272, compound

Participants

Reaction Steps

To a solution of 4-[3-Cyano-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-quinolin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (0.250 g, 0.54 mmole) in 1,4-dioxane (2mL) was treated with 4N HCl in dioxane (5.0 ml). Reaction stirred for 24 h before concentrating to residue and triturating with diethyl ether to afford 1-(4-Fluoro-benzyl)-2-oxo-4-piperazin-1-yl-1,2-dihydro-quinoline-3-carbonitrile hydrochloride salt as a yellow solid (0.195 g, quantitative yield, calc M+H 363, obs M+H 363).

Provenance & Evidence