Hydrochloric Acid → HCID 70874272, compound

HRID 2277427Notes

Reaction equation

HRID 2277427 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]([CH2:24][C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[C:16](=[O:32])[C:15]=2[C:33]#[N:34])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:35]>O1CCOCC1>[ClH:35].[F:31][C:28]1[CH:27]=[CH:26][C:25]([CH2:24][N:17]2[C:18]3[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[C:15]([C:33]#[N:34])[C:16]2=[O:32])=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70873821HCID 70873821, compound

Product 1

HCID 70874272HCID 70874272, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 4-[3-Cyano-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-quinolin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (0.250 g, 0.54 mmole) in 1,4-dioxane (2mL) was treated with 4N HCl in dioxane (5.0 ml). Reaction stirred for 24 h before concentrating to residue and triturating with diethyl ether to afford 1-(4-Fluoro-benzyl)-2-oxo-4-piperazin-1-yl-1,2-dihydro-quinoline-3-carbonitrile hydrochloride salt as a yellow solid (0.195 g, quantitative yield, calc M+H 363, obs M+H 363).

Workup

  1. customReaction
  2. concentrationbefore concentrating to residue
  3. customtriturating with diethyl ether

Sources & evidence

ORD record
ord-0c41ea5411da43dba2efee65032cd73f
Source dataset
uspto-grants-2015_09
Patent number
US09133164B2

Reaction notes

Loading…