4-Cyclopropylbenzeneboronic acid → 2-[5-(4-cyclopropylphenyl)-1-methyl-1H-imidazol-4-yl]pyridine-4-carbonitrile

HRID 2277444Notes

Reaction equation

HRID 2277444 reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[CH:16]1([C:19]2[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=2)[CH2:18][CH2:17]1>>[CH:16]1([C:19]2[CH:24]=[CH:23][C:22]([C:2]3[N:6]([CH3:7])[CH:5]=[N:4][C:3]=3[C:8]3[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=3)=[CH:21][CH:20]=2)[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 28494284-Cyclopropylbenzeneboronic acidHCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

Product 1

HCID 904078452-[5-(4-cyclopropylphenyl)-1-methyl-1H-imidazol-4-yl]pyridine-4-carbonitrile

Procedure

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile and 4-cyclopropylphenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C19H16N4, 301. Found, 301.

Sources & evidence

ORD record
ord-f922e5fca84244f2bf16ff4eec97e6d4
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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