Pyridine, 2-(2-chloroethyl)-, hydrochloride → 2-[1-(pyridin-2-ylmethyl)-1H-imidazol-4-yl]pyridine-4-carbonitrile

HRID 2277488Notes

Reaction equation

HRID 2277488 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1.Cl.ClC[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1>>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:17][N:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 199467Pyridine, 2-(2-chloroethyl)-, hydrochlorideHCID 178510201HCID 178510201, compound

Product 1

HCID 904081122-[1-(pyridin-2-ylmethyl)-1H-imidazol-4-yl]pyridine-4-carbonitrile

Procedure

The title compound was prepared from 2-(1H-imidazol-4-yl)pyridine-4-carbonitrile and 2-(chloroethyl)pyridine hydrogen chloride according to the procedure for the preparation of Example 43, part A. [M+H] Calc'd for C15H11N5, 262. Found, 262.

Sources & evidence

ORD record
ord-9154048d3df644e99bd85bcb101900b1
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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