Trityl chloride → 2-Bromoethyl trityl ether

HRID 2277497노트

반응식

HRID 2277497 반응식
[Br:1][CH2:2][CH2:3][OH:4].CCN(CC)CC.[C:12](Cl)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)Cl>[Br:1][CH2:2][CH2:3][O:4][C:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 3

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 108982-Bromoethanol

생성물 1

HCID 109595312-Bromoethyl trityl ether수율 653.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Bromo-ethanol (6.3 g, 5.0 mmol), Et3N (10 mL, 72 mmol) and trityl chloride (14.6 g, 52.5 mmol) in anhydrous CH2Cl2 (50 mL) was stirred at room temperature overnight and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane/EtOAc, 4:1) to give the title product (12 g).

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by column chromatography on silica gel (hexane/EtOAc, 4:1)

출처 및 근거

ORD 기록
ord-e6392816f01a4057b4a290ed63bda0a4
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133166B2

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