N-bromobutanimide → HCID 90407382, compound

HRID 2277545Notes

Reaction equation

HRID 2277545 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][N:10]1[CH:14]=[C:13]([C:15]2[CH:20]=[C:19]([C:21]#[N:22])[CH:18]=[CH:17][N:16]=2)[N:12]=[CH:11]1.C1C(=O)N([Br:30])C(=O)C1>C(Cl)Cl>[Br:30][C:14]1[N:10]([CH2:9][CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH:11]=[N:12][C:13]=1[C:15]1[CH:20]=[C:19]([C:21]#[N:22])[CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 90408277HCID 90408277, compound

Product 1

HCID 90407382HCID 90407382, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]pyridine-4-carbonitrile (1 eq) in DCM (10 mL) was added NBS (1.05 eq) at rt and stirred for 3 hr at rt. Washed by H2O, dried and concentrated to afford the title compound (95%). [M+H] Calc'd for C17H12BrClN4, 387. Found, 387.

Workup

  1. washWashed by H2O
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f8b86c6ac1d04634969c6ac3ebb7f945
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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