Bromomethylcyclopropane → HCID 90407637, compound

HRID 2277548Notes

Reaction equation

HRID 2277548 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]([NH2:14])=[O:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1.[CH:15]1([CH2:18]Br)[CH2:17][CH2:16]1>>[CH:15]1([CH2:18][N:1]2[CH:5]=[C:4]([C:6]3[CH:11]=[C:10]([C:12]([NH2:14])=[O:13])[CH:9]=[CH:8][N:7]=3)[N:3]=[CH:2]2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 178513687HCID 178513687, compound

Product 1

HCID 90407637HCID 90407637, compoundYield 60%

Procedure

The title compound was prepared in 60% yield from 2-(1H-imidazol-4-yl)pyridine-4-carboxamide (PREPARATION 7) and cyclopropylmethyl bromide according to the procedure for the preparation of Example 124, part A. [M+H] Calc'd for C13H14N4O, 327. Found, 327.

Sources & evidence

ORD record
ord-8737c7d0ed6d44f2add77de11828431e
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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