2-Benzyloxy-4-fluorophenylboronic acid → 2-[5-(4-Fluoro-2-phenylmethoxyphenyl)-1-methylimidazol-4-yl]pyridine-4-carbonitrile

HRID 2277556Notes

Reaction equation

HRID 2277556 reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[CH2:16]([O:23][C:24]1[CH:29]=[C:28]([F:30])[CH:27]=[CH:26][C:25]=1B(O)O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:30][C:28]1[CH:27]=[CH:26][C:25]([C:2]2[N:6]([CH3:7])[CH:5]=[N:4][C:3]=2[C:8]2[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=2)=[C:24]([O:23][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:29]=1

Participants

3

Reactant 2

HCID 27826652-Benzyloxy-4-fluorophenylboronic acidHCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

Product 1

HCID 904081422-[5-(4-Fluoro-2-phenylmethoxyphenyl)-1-methylimidazol-4-yl]pyridine-4-carbonitrile

Procedure

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile (PREPARATION 2) and 2-benzyloxyl-4-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C23H17FN4O, 385. Found, 385.

Sources & evidence

ORD record
ord-44a9609decb34573b453b8fbda47ffe3
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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