反应详情

To a solution of 2-(3-chloro-2-fluoro-phenyl)-ethylamine (1.30 g, 7.9 mmol) in CH2Cl2 (25 mL) was added dropwise methyl chloroformate (1.04 g, 11 mmol) and Et3N at 5° C. with vigorous stirring. The solution was then stirred at room temperature for 1 h. The reaction was poured into ice-water (50 mL) and extracted with CH2Cl2 (2×25 mL). The organic phase was washed with H2O (2×25 mL), dried over Na2SO4, filtered and evaporated to afford the final product without purification (1.78 g, 98%). MS: 232.1 (M+H)+.

1. extractionextracted with CH2Cl2 (2×25 mL)
2. washThe organic phase was washed with H2O (2×25 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated