1,4-Butanesultam → HCID 86679166, compound

HRID 2277657Notes

Reaction equation

HRID 2277657 reaction equation
[S:1]1(=[O:8])(=[O:7])[CH2:6][CH2:5][CH2:4][CH2:3][NH:2]1.[Br:9][C:10]1[CH:11]=[N:12][CH:13]=[C:14]([CH2:16]Cl)[CH:15]=1>>[Br:9][C:10]1[CH:15]=[C:14]([CH2:16][N:2]2[CH2:3][CH2:4][CH2:5][CH2:6][S:1]2(=[O:8])=[O:7])[CH:13]=[N:12][CH:11]=1

Participants

3

Reactant 2

HCID 3035081,4-ButanesultamHCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 86679166HCID 86679166, compound

Procedure

In analogy to the procedure described for the preparation of intermediates B-1 [B], [1,2]thiazinane 1,1-dioxide has been coupled to 3-bromo-5-chloromethyl-pyridine (intermediate B-1 [A]) to yield the title compound as off-white solid. MS: 305.1, 307.1 (M+H+).

Sources & evidence

ORD record
ord-b34e1340c2ab42e8af5b385e118a96c2
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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